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| Hei,Ming-Yan; Tao,Hui-Kang; Tang,Qin; Yu,Bo; Zhao,Ling-Ling. |
| Our objective was to investigate the protein level of phosphorylated N-methyl-D-aspartate (NMDA) receptor-1 at serine 897 (pNR1 S897) in both NMDA-induced brain damage and hypoxic-ischemic brain damage (HIBD), and to obtain further evidence that HIBD in the cortex is related to NMDA toxicity due to a change of the pNR1 S897 protein level. At postnatal day 7, male and female Sprague Dawley rats (13.12 ± 0.34 g) were randomly divided into normal control, phosphate-buffered saline (PBS) cerebral microinjection, HIBD, and NMDA cerebral microinjection groups. Immunofluorescence and Western blot (N = 10 rats per group) were used to examine the protein level of pNR1 S897. Immunofluorescence showed that control and PBS groups exhibited significant neuronal... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: N-methyl-D-aspartate receptor 1; Phosphorylation; Neonate; Hypoxic-ischemic brain damage; Cerebral microinjection; Brain damage. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001000012 |
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| Macongonde,Ernesto A.; Costa,Naithan L.F.; Ferreira,Bruna K.; Biella,Mairis S.; Frederico,Marisa J.S.; Oliveira,Marcos R. de; Ávila Júnior,Silvio; Silva,Fátima R.M.B.; Ferreira,Gustavo C.; Streck,Emilio L.; Schuck,Patrícia F.. |
| Fructose accumulates in tissue and body fluids of patients affected by hereditary fructose intolerance (HFI), a disorder caused by the deficiency of aldolase B. We investigated the effect of acute fructose administration on the biochemical profile and on the activities of the Krebs cycle enzymes in the cerebral cortex of young rats. Rats received a subcutaneous injection of NaCl (0.9 %; control group) or fructose solution (5 μmol/g; treated group). Twelve or 24 h after the administration, the animals were euthanized and the cerebral cortices were isolated. Peripheral blood (to obtain the serum) and cerebral spinal fluid (CSF) from the animals were also collected. It was observed that albumin levels were decreased and cholesterol levels were increased in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brain damage; Fructose; Fructosemia; Hereditary fructose intolerance; Krebs cycle; Metabolism. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301451 |
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